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Article

A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.

The Journal of experimental medicine - 21 Mar 2005

Yoshitomi Hiroyuki, Sakaguchi Noriko, Kobayashi Katsuya, Brown Gordon D, Tagami Tomoyuki, Sakihama Toshiko, Hirota Keiji, Tanaka Satoshi, Nomura Takashi, Miki Ichiro, Gordon Siamon, Akira Shizuo, Nakamura Takashi, Sakaguchi Shimon

Abstract excerpt

A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop autoimmune arthritis, fail to develop the disease under a microbially clean condition, despite active thymic production of arthritogenic autoimmune T cells and their persistence in the periphery. However, in the clean environment, a single intraperitoneal injection of...

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Identifiers

PMID: 15781585
DOI: 10.1084/jem.20041758
PMCID: PMC2213107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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