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Article

Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis.

Cellular & molecular immunology - 1 May 2012

Carvalho Agostinho, Giovannini Gloria, De Luca Antonella, D'Angelo Carmen, Casagrande Andrea, Iannitti Rossana G, Ricci Giovanni, Cunha Cristina, Romani Luigina

Abstract excerpt

The recognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6, but not BALB/c mice;...

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Identifiers

PMID: 22543832
DOI: 10.1038/cmi.2012.1
PMCID: PMC4012853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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