Article
Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice.
Arthritis research & therapy - 19 Aug 2015
Lee Ellen J, Vance Emily E, Brown Brieanna R, Snow Paige S, Clowers Jenna S, Sakaguchi Shimon, Rosenzweig Holly L
Abstract excerpt
INTRODUCTION: Systemic rheumatic conditions are often accompanied by intraocular inflammatory disease (termed uveitis). Despite the frequent manifestation of uveitis with arthritis, very little is understood of the underlying mechanisms that mediate the eye's susceptibility to disease. The genetically susceptible SKG mouse strain develops arthritis that arises from an inherent mutation that disrupts T-cell...
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