Article
Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.
Journal of autoimmunity - 1 Sept 2016
Chevalier Nina, Tan Jian K, Mason Linda J, Robert Remy, McKenzie Craig I, Lim Florence, Wong Connie H, Macia Laurence, Thorburn Alison N, Russ Brendan E, Masters Seth L, Mackay Charles R
Abstract excerpt
Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal inflammation, cigarette smoking, periodontal disease, and various infections. The cellular and, molecular pathways whereby such remote challenges might precipitate arthritis or flares remain unclear. Here, we used a transfer model of self-reactive arthritis-inducing CD4(+)...
Topics
- Adoptive Transfer
- Animals
- Arthritis, Experimental
- Arthritis, Rheumatoid
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Colitis
- Dextran Sulfate
- Genetic Predisposition to Disease
- Influenza A virus
- Interleukin-17
- Interleukin-1beta