Article
The NQO1 C609T polymorphism and risk of lung cancer: a meta-analysis.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011
Liu Yin, Zhang Deping
Abstract excerpt
OBJECTIVE: NAD(P)H: quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two- electron reduction of quinoid compounds into hydroquinones. A single base substitution (C?T) polymorphism at 609 in the NQO1 gene reduces quinone reductase activity. Published data on the association between NQO1 C609T polymorphism and lung cancer risk are conflicting. METHODS: To derive a more precise...
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