A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population.

doi:10.1007/s13277-012-0509-x

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Article

A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2013

Liu Fei, Luo Limei, Wei Yonggang, Wang Wentao, Li Bo, Yan Lvnan, Wen Tianfu

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two-electron reduction of quinoid compounds into hydroquinones, thus protecting cells from oxidative damage. A single base substitution (C→T) polymorphism at 609 in the NQO1 gene reduces quinone reductase activity. Thus, the lack of enzymatic activity in the homozygous C609T NQO1 polymorphism (rs1800566) may play a pivotal role...

Topics

Carcinoma, Hepatocellular
Case-Control Studies
China
Female
Genetic Predisposition to Disease
Genotype
Hepatitis B Surface Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver Neoplasms

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Polymorphism, Single Nucleotide

Risk

Source

Open in PubMed

Identifiers

PMID: 22972504
DOI: 10.1007/s13277-012-0509-x

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22972504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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