Article
NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study.
Carcinogenesis - 1 Feb 2005
Bock C H, Wenzlaff A S, Cote M L, Land S J, Schwartz A G
Abstract excerpt
The NAD(P)H:quinone oxidoreductase 1 gene, NQO1, contains a C to T transition at amino acid codon 187, which results in very low enzymatic activity. Previous studies of the association between NQO1 genotype and lung cancer have had mixed findings. This population-based case control study examines the association between NQO1 genotype and lung cancer in the largest sample of never smokers (<100 cigarettes,...
Topics
- Adult
- Aged
- Alleles
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)