Article
Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.
Molecular cell - 18 Mar 2005
Mason Paul B, Struhl Kevin
Abstract excerpt
A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivity (nucleotide additions per initiation event) in vivo are poorly understood. Here, we show that a mutation in the Rpb2 subunit of Pol II reduces both the elongation rate and processivity in vivo....
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