Article
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C.
Nature structural & molecular biology - 1 Apr 2005
Gong Chunling, Bongiorno Paola, Martins Alexandra, Stephanou Nicolas C, Zhu Hui, Shuman Stewart, Glickman Michael S
Abstract excerpt
DNA double-strand breaks (DSBs) can be repaired either via homologous recombination (HR) or nonhomologous end-joining (NHEJ). Both pathways are operative in eukaryotes, but bacteria had been thought to rely on HR alone. Here we provide direct evidence that mycobacteria have a robust NHEJ pathway that requires Ku and a specialized polyfunctional ATP-dependent DNA ligase (LigD). NHEJ of blunt-end and complementary...
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