Article
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Science (New York, N.Y.) - 22 Oct 2004
Della Marina, Palmbos Phillip L, Tseng Hui-Min, Tonkin Louise M, Daley James M, Topper Leana M, Pitcher Robert S, Tomkinson Alan E, Wilson Thomas E, Doherty Aidan J
Abstract excerpt
In mammalian cells, repair of DNA double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ) is critical for genome stability. Although the end-bridging and ligation steps of NHEJ have been reconstituted in vitro, little is known about the end-processing reactions that occur before ligation. Recently, functionally homologous end-bridging and ligation activities have been identified in prokarya. Consistent...
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