Article
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Science (New York, N.Y.) - 22 Oct 2004
Della Marina, Palmbos Phillip L, Tseng Hui-Min, Tonkin Louise M, Daley James M, Topper Leana M, Pitcher Robert S, Tomkinson Alan E, Wilson Thomas E, Doherty Aidan J
Abstract excerpt
In mammalian cells, repair of DNA double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ) is critical for genome stability. Although the end-bridging and ligation steps of NHEJ have been reconstituted in vitro, little is known about the end-processing reactions that occur before ligation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.