Article
Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014
Qu Yibo, Huang Yuhua, Feng Jia, Alvarez-Bolado Gonzalo, Grove Elizabeth A, Yang Yingzi, Tissir Fadel, Zhou Libing, Goffinet Andre M
Abstract excerpt
Celsr3 and Fzd3, members of "core planar cell polarity" (PCP) genes, were shown previously to control forebrain axon guidance and wiring by acting in axons and/or guidepost cells. Here, we show that Celsr2 acts redundantly with Celsr3, and that their combined mutation mimics that of Fzd3. The phenotypes generated upon inactivation of Fzd3 in different forebrain compartments are similar to those in conditional...
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