Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS.

doi:10.1016/j.ijdevneu.2008.07.004

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Article

Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Nov 2008

Dorsten Joy N, VanBerkum Mark F A

Abstract excerpt

Frazzled is a Netrin-dependent chemoattractive receptor required for axon pathway formation in the developing Drosophila embryonic CNS. The cytoplasmic domain is important and contains three conserved P-motifs (P1, P2, and P3) thought to initiate intracellular signaling cascades and to crosstalk with other receptors during axon pathway formation. Here, we rescue homozygous frazzled embryos by pan-neurally...

Topics

Amino Acid Motifs
Animals
Axons
Central Nervous System
Cytoplasm
Drosophila
Drosophila Proteins
Functional Laterality
Gene Expression Regulation, Developmental
Growth Cones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Neurons

Mutation

Netrin Receptors

Neural Pathways

Neurogenesis

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 18674607
DOI: 10.1016/j.ijdevneu.2008.07.004

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