Article
The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.
Blood - 1 Jul 2005
Whitman Susan P, Liu Shujun, Vukosavljevic Tamara, Rush Laura J, Yu Li, Liu Chunhui, Klisovic Marko I, Maharry Kati, Guimond Martin, Strout Matthew P, Becknell Brian, Dorrance Adrienne, Klisovic Rebecca B, Plass Christoph, Bloomfield Clara D, Marcucci Guido, Caligiuri Michael A
Abstract excerpt
MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloid leukemia (AML) blasts with the t(9;11)(p22; q23) express MLL-AF9 and MLL wild-type (WT) transcripts, while normal karyotype AML blasts with the MLL(PTD/WT) genotype express MLL PTD but not the MLL WT. Silencing of MLL WT in MLL(PTD/WT) blasts was reversed by DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.