Article
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line.
FEBS letters - 27 Apr 1992
Kelleher D, Long A
Abstract excerpt
In the human T-cell lymphoma line, HuT 78, proliferation and phorbol ester-induced growth arrest and differentiation were inhibited by the protein kinase C (PKC) inhibitor, staurosporine. By contrast, an alternative PKC inhibitor, H-7, inhibited proliferation but not phorbol ester-induced growth arrest. The cell line was found to contain both alpha and beta isoforms of PKC by Western blot techniques. A cell line,...
Topics
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Alkaloids
- Blotting, Western
- Cell Differentiation
- Cell Division
- Cell Line
- Flow Cytometry
- Humans
- Interleukin-2
- Isoenzymes
- Isoquinolines
- Phenotype