Article
Effects of PKC inhibitors on suppression of thermotolerance development in tsAF8 cells.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000
Shibuya K, Kawasaki S, Kuroda M, Asaumi J, Kanazawa S, Hiraki Y
Abstract excerpt
Effects of protein kinase C (PKC) inhibitors (H7, staurosporine, calphostin C) on thermotolerance development were investigated in temperature sensitive tsAF8 cells derived from Syrian hamster BHK21 cells. Cells were pre-heated at 45 degrees C for 20 min, incubated at 34 degrees C with PKC inhibitors for varying lengths of time, i.e. 1.25-10.0 h, and then heated at 45 degrees C for 30 min. Increasing survival...
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