Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines.

doi:10.1016/s0304-3835(99)00021-x

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Article

Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines.

Cancer letters - 24 May 1999

Mohan D R, Nagarathna R, Krishna M, Jagtap J C, Shastry P

Abstract excerpt

We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A differential response to SSP treatment in the enzyme activity in whole cell lysate and particulate...

Topics

Animals
Cell Division
Dose-Response Relationship, Drug
Enzyme Inhibitors
Growth Inhibitors
Mice
Neuroblastoma
Phenotype
Protein Kinase C
Staurosporine
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 10395170
DOI: 10.1016/s0304-3835(99)00021-x

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