Article
Defective microtubule reorganization in phorbol ester-resistant U937 variants: reconstitution of the normal cell phenotype with nocodazole treatment.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1997
Kiley S C, Parker P J
Abstract excerpt
Phorbol ester-induced beta 2-integrin transport to the cell surface is defective in cloned 12-O-tetradecanoylphorbol-13-acetate (TPA)-resistant U937 cell variants. Failure of the integrin-containing vesicles to reach the plasma membrane effectively blocks development of all integrin-mediated resp...
Topics
- Antineoplastic Agents
- Cell Adhesion
- Clone Cells
- Drug Resistance
- Flow Cytometry
- Humans
- Leukemia, Promyelocytic, Acute
- Microtubule-Associated Proteins
- Microtubules
- NADPH Oxidases
- Nocodazole
- Phenotype
- Protein Binding
- Protein Kinase C
- Tetradecanoylphorbol Acetate
- Tumor Cells, Cultured