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Article

Defective microtubule reorganization in phorbol ester-resistant U937 variants: reconstitution of the normal cell phenotype with nocodazole treatment.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1997

Kiley S C, Parker P J

Abstract excerpt

Phorbol ester-induced beta 2-integrin transport to the cell surface is defective in cloned 12-O-tetradecanoylphorbol-13-acetate (TPA)-resistant U937 cell variants. Failure of the integrin-containing vesicles to reach the plasma membrane effectively blocks development of all integrin-mediated responses and the formation of a functional oxidase complex. Several lines of evidence suggested that the underlying cause...

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PMID: 9040945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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