New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1

Abstract excerpt

Last year, a little known G protein-coupled receptor, GPR54, was unexpectedly catapulted to a key regulatory position within the hypothalamic-pituitary-gonadal axis. Several lines of evidence supported the role of GPR54 as gatekeeper of the reproductive cascade. In the human, loss-of-function point mutations and deletions within the coding sequence of the GPR54 gene were identified in patients with idiopathic...

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