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Article

Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction

1 Jun 2008

Abstract excerpt

In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context...

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PMID: 18601695
DOI: 10.1111/j.1365-2826.2008.01731.x

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