Article
Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1993
Brinkmann U, Lee B K, Pastan I
Abstract excerpt
We prepared recombinant immunotoxins in Escherichia coli in which the VH or VL domains of mAb B3 were fused to a truncated form of Pseudomonas exotoxin (PE) (PE38KDEL). mAb B3 binds to a carbohydrate Ag found on the surfaces of many types of cancers and only a few normal tissues. PE38KDEL is a 38...
Topics
- ADP Ribose Transferases
- Amino Acid Sequence
- Amino Acids
- Antibodies, Monoclonal
- Antibody Specificity
- Bacterial Toxins
- Base Sequence
- Exotoxins
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunotoxins
- Molecular Sequence Data
- Mutation
- Plasmids
- Pseudomonas aeruginosa
- Recombinant Fusion Proteins