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Article

Membrane insertion of the N-terminal alpha-helix of equinatoxin II, a sea anemone cytolytic toxin.

The Biochemical journal - 1 Dec 2004

Gutiérrez-Aguirre Ion, Barlic Ariana, Podlesek Zdravko, Macek Peter, Anderluh Gregor, González-Mañas Juan M

Abstract excerpt

Equinatoxin II (Eqt-II) is a member of the actinoporins, a unique family of cytotoxins comprising 20 kDa pore-forming proteins isolated from sea anemones. Actinoporins bind preferentially to lipid membranes containing sphingomyelin, and create cation-selective pores by oligomerization of three to four monomers. Previous studies have shown that regions of Eqt-II crucial for its cytolytic mechanism are an exposed...

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Identifiers

PMID: 15317486
DOI: 10.1042/BJ20040601
PMCID: PMC1134126

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Source receipt: pubmed, retrieved 7 Sept 2026.

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