Article
Pore formation by equinatoxin, a eukaryotic pore-forming toxin, requires a flexible N-terminal region and a stable beta-sandwich.
The Journal of biological chemistry - 5 Nov 2004
Kristan Katarina, Podlesek Zdravko, Hojnik Vesna, Gutiérrez-Aguirre Ion, Guncar Gregor, Turk Dusan, González-Mañas Juan M, Lakey Jeremy H, Macek Peter, Anderluh Gregor
Abstract excerpt
Actinoporins are eukaryotic pore-forming proteins that create 2-nm pores in natural and model lipid membranes by the self-association of four monomers. The regions that undergo conformational change and form part of the transmembrane pore are currently being defined. It was shown recently that the N-terminal region (residues 10-28) of equinatoxin, an actinoporin from Actinia equina, participates in building of...
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