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Article

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.

Molecular and cellular biology - 1 Apr 2005

Okuno Yutaka, Huang Gang, Rosenbauer Frank, Evans Erica K, Radomska Hanna S, Iwasaki Hiromi, Akashi Koichi, Moreau-Gachelin Francoise, Li Youlin, Zhang Pu, Göttgens Berthold, Tenen Daniel G

Abstract excerpt

Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role in the development of white cells, and abnormal expression of PU.1 can lead to leukemia. We previously reported that the PU.1 promoter cannot induce expression of a reporter gene in vivo, and cell-type-specific expression of PU.1 in stable lines was conferred by a 3.4-kb DNA fragment including a DNase I hypersensitive site...

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Identifiers

PMID: 15767686
DOI: 10.1128/MCB.25.7.2832-2845.2005
PMCID: PMC1061634

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.PMID 15767686Read ↗

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