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Article

Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Molecular and cellular biology - 1 Dec 2005

Lamsoul Isabelle, Lodewick Julie, Lebrun Sylvie, Brasseur Robert, Burny Arsène, Gaynor Richard B, Bex Françoise

Abstract excerpt

The transcription factor NF-kappaB is critical for the induction of cancer, including adult T-cell leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the expression of its regulatory protein Tax. Although activation of the NF-kappaB pathway by Tax involves its interaction with the regulatory subunit of the IkappaB kinase (IKK) complex, NEMO/IKKgamma, the mechanism by which Tax...

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Identifiers

PMID: 16287853
DOI: 10.1128/MCB.25.23.10391-10406.2005
PMCID: PMC1291224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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