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Article

Ikaros isoforms: The saga continues

1 Jan 2011

Abstract excerpt

Through alternate splicing, the Ikaros gene produces multiple proteins. Ikaros is essential for normal hematopoiesis and possesses tumor suppressor activity. Ikaros isoforms interact to form dimers and potentially multimeric complexes. Diverse Ikaros complexes produced by the presence of different Ikaros isoforms are hypothesized to confer distinct functions. Small dominant-negative Ikaros isoforms have been...

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PMID: 21765980
DOI: 10.4331/wjbc.v2.i6.140

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