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Article

Effect of MDR1 haplotype on risk of Parkinson disease.

Archives of neurology - 1 Mar 2005

Tan Eng-King, Chan Daniel Kam-Yin, Ng Ping-Wing, Woo Jean, Teo Y Y, Tang Kun, Wong Li-Peng, Chong Samuel S, Tan Chris, Shen Hui, Zhao Yi, Lee Caroline G L

Abstract excerpt

BACKGROUND: MDR1, a multidrug transporter, encodes a P-glycoprotein that regulates the bioavailability of xenobiotics and is highly expressed at the blood-brain-barrier. Two single nucleotide polymorphisms (SNPs) (e21/2677[G/T/A] and e26/3435[C/T]) in the MDR1 gene can lead to differences in MDR1 expression and function. Specific MDR1 alleles of the 2 SNPs are positively selected among ethnic Chinese but not in...

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Identifiers

PMID: 15767512
DOI: 10.1001/archneur.62.3.460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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