Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of adult mouse neurovirulence determinants of the Sindbis virus strain AR86.

Journal of virology - 1 Apr 2005

Suthar Mehul S, Shabman Reed, Madric Kenya, Lambeth Cassandra, Heise Mark T

Abstract excerpt

Sindbis virus infection of mice has provided valuable insight into viral and host factors that contribute to virus-induced neurologic disease. In an effort to further define the viral genetic elements that contribute to adult mouse neurovirulence, the neurovirulent Sindbis virus strain AR86 was compared to the closely related (22 single amino acid coding changes and the presence or absence of an 18-amino-acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alphavirus Infections
Share to Cricetinae
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Sindbis Virus

Share to Spinal Cord

Share to Viral Envelope Proteins

Share to Viral Nonstructural Proteins

Share to Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 15767423
DOI: 10.1128/JVI.79.7.4219-4228.2005
PMCID: PMC1061553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of adult mouse neurovirulence determinants of the Sindbis virus strain AR86.PMID 15767423Read ↗

A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT SignalingSemantic proximity Read ↗

Genetic determinants of Sindbis virus neuroinvasivenessSemantic proximity Read ↗

A Single Amino Acid Change in nsP1 Attenuates Neurovirulence of the Sindbis-Group Alphavirus S.A.AR86Semantic proximity Read ↗

Viral determinants of age-dependent virulence of Sindbis virus for miceSemantic proximity Read ↗

An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.Semantic proximity Read ↗

Mapping Attenuation Determinants in Enterovirus-D68Semantic proximity Read ↗

An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.Semantic proximity Read ↗

Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response SyndromeSemantic proximity Read ↗

Replicase Complex Genes of Semliki Forest Virus Confer Lethal NeurovirulenceSemantic proximity Read ↗

Attenuating mutations in glycoproteins E1 and E2 of Sindbis virus produce a highly attenuated strain when combined in vitro.Semantic proximity Read ↗

Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model.Semantic proximity Read ↗

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.