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Article

Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome

1 Dec 1999

Abstract excerpt

Laboratory strains of viruses may contain cell culture-adaptive mutations which result in significant quantitative and qualitative alterations in pathogenesis compared to natural virus isolates. This report suggests that this is the case with Sindbis virus strain AR339. A cDNA clone comprising a consensus sequence of Sindbis virus strain AR339 has been constructed (W. B. Klimstra, K. D. Ryman, and R. E. Johnston,...

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PMID: 10559357
DOI: 10.1128/jvi.73.12.10387-10398.1999

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