Article
An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.
Virology - 20 Jan 2013
Wollish Amy C, Ferris Martin T, Blevins Lance K, Loo Yueh-Ming, Gale Michael, Heise Mark T
Abstract excerpt
The AR86 strain of Sindbis virus causes lethal neurologic disease in adult mice. Previous studies have identified a virulence determinant at nonstructural protein (nsP) 1 position 538 that regulates neurovirulence, modulates clearance from the CNS, and interferes with the type I interferon pathway. The studies herein demonstrate that in the absence of type I interferon signaling, the attenuated mutant exhibited...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.