Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replicase Complex Genes of Semliki Forest Virus Confer Lethal Neurovirulence

15 May 2000

Abstract excerpt

Semliki Forest virus (SFV) is a mosquito-transmitted pathogen of small rodents, and infection of adult mice with SFV4, a neurovirulent strain of SFV, leads to lethal encephalitis in a few days, whereas mice infected with the avirulent A7(74) strain remain asymptomatic. In adult neurons, A7(74) is unable to form virions and hence does not reach a critical threshold of neuronal damage. To elucidate the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10775594
DOI: 10.1128/jvi.74.10.4579-4589.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replicase Complex Genes of Semliki Forest Virus Confer Lethal NeurovirulencePMID 10775594Read ↗

Amino acid mutations in the replicase protein nsP3 of Semliki Forest virus cumulatively affect neurovirulence.Semantic proximity Read ↗

Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest VirusSemantic proximity Read ↗

The significance of the 3'-nontranslated region and E2 amino acid mutations in the virulence of Semliki Forest virus in mice.Semantic proximity Read ↗

A Single Amino Acid Change in the Nuclear Localization Sequence of the nsP2 Protein Affects the Neurovirulence of Semliki Forest VirusSemantic proximity Read ↗

Pathogenesis of Semliki Forest Virus EncephalitisSemantic proximity Read ↗

Attenuation of Semliki Forest Virus Neurovirulence by MicroRNA-Mediated DetargetingSemantic proximity Read ↗

The type I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues, but does not mediate the restricted replication of avirulent virus in central nervous system neuronsSemantic proximity Read ↗

A Novel Neurotropic Expression Vector Based on the Avirulent A7(74) Strain of Semliki Forest VirusSemantic proximity Read ↗

The Pathogenesis of AlphavirusesSemantic proximity Read ↗

The molecular pathogenesis of Semliki Forest virus: a model virus made useful?Semantic proximity Read ↗

Semliki Forest virus A7(74) transduces hippocampal neurons and glial cells in a temperature-dependent dual manner.Semantic proximity Read ↗

Viral Determinants of Virulence in Tick-Borne FlavivirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.