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Article

Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model.

Virology - 5 Feb 2011

Jupille Henri J, Oko Lauren, Stoermer Kristina A, Heise Mark T, Mahalingam Suresh, Gunn Bronwyn M, Morrison Thomas E

Abstract excerpt

The viral determinants of alphavirus-induced rheumatic disease have not been elucidated. We identified an RRV strain (DC5692) which, in contrast to the T48 strain, does not induce musculoskeletal inflammation in a mouse model of RRV disease. Substitution of the RRV T48 strain nonstructural protein 1 (nsP1) coding sequence with that from strain DC5692 generated a virus that was attenuated in vivo despite similar...

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Identifiers

PMID: 21131014
DOI: 10.1016/j.virol.2010.11.012
PMCID: PMC3017666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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