Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population.

doi:10.3346/jkms.2011.26.6.720

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Article

Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population.

Journal of Korean medical science - 1 Jun 2011

Eom Sang-Yong, Kim Yun-Sik, Lee Chung-Jong, Lee Chul-Ho, Kim Yong-Dae, Kim Heon

Abstract excerpt

Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity. In this study, we investigated the association between 3 polymorphisms of PON1 located in intron 5 (17899insdelTT and 17974CT) and exon 6 (192QR) and serum PON1 activity. The genetic polymorphisms and serum activity...

Topics

Aged
Alleles
Aryldialkylphosphatase
Asian People
Exons
Female
Gene Frequency
Genotype
Humans
Introns
Linkage Disequilibrium
Lipoproteins, HDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Regression Analysis

Republic of Korea

Source

Open in PubMed Open full text

Identifiers

PMID: 21655055
DOI: 10.3346/jkms.2011.26.6.720
PMCID: PMC3102863

Genes

PON1

Provenance

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