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Article

Variant of human enzyme sequesters reactive intermediate.

Biochemistry - 22 Mar 2005

Ewalt Karla L, Yang Xiang-Lei, Otero Francella J, Liu Jianming, Slike Bonnie, Schimmel Paul

Abstract excerpt

In cellular environments, coupled hydrolytic reactions are used to force efficient product formation in enzyme-catalyzed reactions. In the first step of protein synthesis, aminoacyl-tRNA synthetases react with amino acid and ATP to form an enzyme-bound adenylate that, in the next step, reacts wit...

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Identifiers

PMID: 15766249
DOI: 10.1021/bi048116l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15766249-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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