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Article

A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase.

The Journal of biological chemistry - 3 Jan 2003

Paoli Paolo, Pazzagli Luigia, Giannoni Elisa, Caselli Anna, Manao Giampaolo, Camici Guido, Ramponi Giampietro

Abstract excerpt

Acylphosphatase, one of the smallest enzymes, is expressed in all organisms. It displays hydrolytic activity on acyl phosphates, nucleoside di- and triphosphates, aryl phosphate monoesters, and polynucleotides, with acyl phosphates being the most specific substrates in vitro. The mechanism of catalysis for human acylphosphatase (the organ-common type isoenzyme) was investigated using both aryl phosphate...

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Identifiers

PMID: 12409302
DOI: 10.1074/jbc.M206918200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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