Article
Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases.
PLoS computational biology - 1 Apr 2018
Kaiser Florian, Bittrich Sebastian, Salentin Sebastian, Leberecht Christoph, Haupt V Joachim, Krautwurst Sarah, Schroeder Michael, Labudde Dirk
Abstract excerpt
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed that these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different...
Topics
- Adenosine Triphosphate
- Amino Acid Sequence
- Amino Acyl-tRNA Synthetases
- Arginine
- Base Sequence
- Catalytic Domain
- Codon
- Computational Biology
- Evolution, Molecular
- Genetic Variation
- Humans
- Ligands
- Models, Molecular