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Article

Enzyme catalysis: a new definition accounting for noncovalent substrate- and product-like states.

Trends in biochemical sciences - 1 Jul 2001

Purich D L

Abstract excerpt

Biological catalysis frequently causes changes in noncovalent bonding. By building on Pauling's assertion that any long-lived, chemically distinct interaction is a chemical bond, this article redefines enzyme catalysis as the facilitated making and/or breaking of chemical bonds, not just of covalent bonds. It is also argued that nearly every ATPase or GTPase is misnamed as a hydrolase and actually belongs to a...

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Identifiers

PMID: 11440852
DOI: 10.1016/s0968-0004(01)01880-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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