Article
Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2005
Nahon Pierre, Sutton Angéla, Pessayre Dominique, Rufat Pierre, Degoul Francoise, Ganne-Carrie Nathalie, Ziol Marianne, Charnaux Nathalie, N'kontchou Gisèle, Trinchet Jean-Claude, Gattegno Liliane, Beaugrand Michel
Abstract excerpt
BACKGROUND AND AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import. However, the role of this dimorphism in the susceptibility of alcoholic patients to develop cirrhosis is controversial, and its influence on the occurrence of hepatocellular carcinoma (HCC) and death in...
Topics
- Carcinoma, Hepatocellular
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Liver Cirrhosis, Alcoholic
- Liver Neoplasms
- Male
- Middle Aged
- Prospective Studies