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Article

Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis.

Journal of gastroenterology and hepatology - 1 Feb 2002

Frenzer Andreas, Butler Wendy J, Norton Ian D, Wilson Jeremy S, Apte Minoti V, Pirola Romano C, Ryan Philip, Roberts-Thomson Ian C

Abstract excerpt

BACKGROUND AND AIM: Susceptibility to organ damage induced by alcohol may be due to inherited variation (polymorphism) in ethanol-metabolizing enzymes, or to polymorphisms affecting free radical or lipid metabolism mediated by enzymes such as glutathione S-transferases and apolipoprotein E. The aim was to compare the genotype frequencies of alcohol dehydrogenase-2 (ADH2), ADH3, aldehyde dehydrogenase-2 (ALDH2),...

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Share to Alcohol Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2E1

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Share to Liver Cirrhosis, Alcoholic

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Source

Identifiers

PMID: 11966948
DOI: 10.1046/j.1440-1746.2002.02670.x

Genes

ALDH2
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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