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Article

Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis.

Archives of internal medicine - 12 Sept 2005

Stickel Felix, Osterreicher Christoph H, Datz Christian, Ferenci Peter, Wölfel Marco, Norgauer Wolfgang, Kraus Michael R, Wrba Fritz, Hellerbrand Claus, Schuppan Detlef

Abstract excerpt

BACKGROUND: Oxidative stress plays an important pathogenic role in hereditary hemochromatosis (HHC) and chronic hepatitis C virus infection (CHC). Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (MnSOD), reveal polymorphisms that affect their antioxidant capacity and may therefore modulate the...

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Source

Identifiers

PMID: 16157826
DOI: 10.1001/archinte.165.16.1835

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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