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Article

The manganese superoxide dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells.

Free radical biology & medicine - 1 Nov 2008

Nahon Pierre, Charnaux Nathalie, Friand Véronique, Prost-Squarcioni Catherine, Ziol Marianne, Lièvre Nicole, Trinchet Jean-Claude, Beaugrand Michel, Gattegno Liliane, Pessayre Dominique, Sutton Angela

Abstract excerpt

The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity. In alcoholic cirrhotic patients, the Ala-MnSOD allele is associated with hepatic iron accumulation and an increased risk of hepatocellular carcinoma. The Ala-MnSOD variant could modulate the expression of proteins...

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Identifiers

PMID: 18760346
DOI: 10.1016/j.freeradbiomed.2008.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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