Article
Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
Hepatology (Baltimore, Md.) - 1 Nov 2009
Nahon Pierre, Sutton Angela, Rufat Pierre, Ziol Marianne, Akouche Hassan, Laguillier Christelle, Charnaux Nathalie, Ganne-Carrié Nathalie, Grando-Lemaire Véronique, N'Kontchou Gisèle, Trinchet Jean-Claude, Gattegno Liliane, Pessayre Dominique, Beaugrand Michel
Abstract excerpt
UNLABELLED: Alcohol increases reactive oxygen species (ROS) formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils. Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the...
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