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Article

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.

Journal of hepatology - 1 Feb 2012

Nahon Pierre, Sutton Angela, Rufat Pierre, Charnaux Nathalie, Mansouri Abdellah, Moreau Richard, Ganne-Carrié Nathalie, Grando-Lemaire Véronique, N'Kontchou Gisèle, Trinchet Jean-Claude, Pessayre Dominique, Beaugrand Michel

Abstract excerpt

BACKGROUND & AIMS: Genetic dimorphisms modulate the activities of several pro- or antioxidant enzymes, including myeloperoxidase (MPO), catalase (CAT), manganese superoxide dismutase (SOD2), and glutathione peroxidase 1 (GPx1). We assessed the role of the G(-463)A-MPO, T(-262)C-CAT, Ala16Val-SOD2, and Pro198Leu-GPx1 variants in modulating HCC development in patients with HCV-induced cirrhosis. METHODS: Two...

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Source

Identifiers

PMID: 21907168
DOI: 10.1016/j.jhep.2011.08.010

Genes

MPO
CAT
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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