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Article

Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis.

Cancer research - 1 Mar 2006

Sutton Angela, Nahon Pierre, Pessayre Dominique, Rufat Pierre, Poiré Aurélie, Ziol Marianne, Vidaud Dominique, Barget Nathalie, Ganne-Carrié Nathalie, Charnaux Nathalie, Trinchet Jean-Claude, Gattegno Liliane, Beaugrand Michel

Abstract excerpt

Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds. We investigated the role of Ala/Val-MnSOD and Pro/Leu-GPx1 polymorphisms on hepatic iron accumulation and hepatocellular carcinoma development in patients with alcoholic cirrhosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16510607
DOI: 10.1158/0008-5472.CAN-05-2566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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