Article
Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis.
Hepatology (Baltimore, Md.) - 1 Dec 2002
Stewart Stephen F, Leathart Julian B, Chen Yuanneng, Daly Ann K, Rolla Roberta, Vay Daria, Mottaran Elisa, Vidali Matteo, Albano Emanuele, Day Chris P
Abstract excerpt
The role of genetic factors in the pathogenesis of alcohol-induced liver disease (ALD) is receiving increasing attention. Recently, it has been reported that homozygosity for a valine to alanine substitution in the mitochondrial targeting sequence of manganese superoxide dismutase (Mn-SOD) represents a risk factor for severe ALD. Because this mutation is postulated to modify enzyme transport into mitochondria, we...
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