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Article

Partial genetic deficiency in tissue kallikrein impairs adaptation to high potassium intake in humans.

Kidney international - 1 Dec 2013

Monteiro Joana S, Blanchard Anne, Curis Emmanuel, Chambrey Régine, Jeunemaitre Xavier, Azizi Michel

Abstract excerpt

Inactivation of the tissue kallikrein gene in mice impairs renal handling of potassium due to enhanced H, K-ATPase activity, and induces hyperkalemia. We investigated whether the R53H loss-of-function polymorphism of the human tissue kallikrein gene affects renal potassium handling. In a crossover study, 30 R53R homozygous and 10 R53H heterozygous healthy males were randomly assigned to a...

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Identifiers

PMID: 23760292
DOI: 10.1038/ki.2013.224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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