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Article

Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity.

Journal of the American Society of Nephrology : JASN - 1 Apr 2002

Slim Rola, Torremocha Florence, Moreau Thierry, Pizard Anne, Hunt Steven C, Vuagnat Albert, Williams Gordon H, Gauthier Francis, Jeunemaitre Xavier, Alhenc-Gelas François

Abstract excerpt

Kallikrein is synthesized in the distal tubules and produces kinins, which are involved in the regulation of vascular tone in the kidney. Urinary kallikrein activity has been reported to be partly inherited and to be reduced in essential hypertension. In a systematic search for molecular variants of the human kallikrein gene, nine single-nucleotide polymorphisms were identified. Five of those polymorphisms,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11912256
DOI: 10.1681/ASN.V134968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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