Article
Regulation and role of Raf-1/B-Raf heterodimerization.
Molecular and cellular biology - 1 Mar 2006
Rushworth Linda K, Hindley Alison D, O'Neill Eric, Kolch Walter
Abstract excerpt
The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental cellular processes including proliferation, survival, and differentiation. The pathway is deregulated in up to 30% of human cancers, often due to mutations in Ras and the B-Raf isoform. Raf-1 and B-Raf can form heterodimers, and this may be important for cellular transformation. Here, we have...
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