Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma:TP63is amplified in early carcinogenesis but down-regulated as disease progressed

Abstract excerpt

AIM: By using comparative genomic hybridization, gain of 3q was found in 45-86% cases of esophageal squamous cell carcinoma (EC-SCC). Chromosome 3q25.3-qter is the minimal common region with several oncogenes found within this region. However, amplification patterns of these genes in EC-SCC have never been reported. The possible association of copy number changes of these genes with pathologic characteristics is...

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