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Article

Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2012

Lockwood William W, Thu Kelsie L, Lin Lin, Pikor Larissa A, Chari Raj, Lam Wan L, Beer David G

Abstract excerpt

PURPOSE: Esophageal adenocarcinoma (EAC) is a lethal malignancy that can develop from the premalignant condition, Barrett's esophagus (BE). Currently, there are no validated simple methods to predict which patients will progress to EAC. A better understanding of the genetic mechanisms driving EAC tumorigenesis is needed to identify new therapeutic targets and develop biomarkers capable of identifying high-risk...

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Share to Comparative Genomic Hybridization
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

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Source

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Identifiers

PMID: 22328562
DOI: 10.1158/1078-0432.CCR-11-1431
PMCID: PMC3523177

Genes

RFC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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