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Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma

9 Feb 2009

Abstract excerpt

The genomic region containing PIK3CA was found to be amplified in esophageal squamous cell carcinoma (ESCC) tissue. PIK3CA at 3q26, which encodes the p110alpha catalytic subunit of phosphatidylinositol (PI) 3-kinase, is a unique intracellular signal transducer characterized by its lipid substrate specificity. In order to characterize PIK3CA in ESCC, we investigated hot-spot mutations in exons 1, 9 and 20, the...

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PMID: 19212681
DOI: 10.3892/ijo_00000202

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